The resurgence of the New World screwworm in Mexico poses a direct threat to the U.S. livestock industry, wildlife, and food security. USDA's decisive action, including a new dispersal facility in Texas and a comprehensive five-pronged strategy, marks a pivotal escalation in efforts to prevent a devastating outbreak. The plan reinforces biosecurity along the southern border, invests in domestic sterile fly production, and fosters innovation to ensure the U.S. remains free of this deadly pest.